The relevance of the discourse of global spectrum regulation cannot be overemphasized. This is due to its vitality as a requisite for growth enhancement in the digital economy. The use of spectrum resources natural resources commands a high range of attention considering its trans-continental and national spread. Electromagnetic are boundless waves that demands a concerted effort of control and balance. This paper discussed the meaning of spectrum, its management, international organizations and regulations, and highlights regional and national organizations/regulations. The paper also discussed the key principles of spectrum management, how to achieve Spectrum Management, challenges, Global Best Practices for Effective Spectrum Regulation. The paper made recommendations and concluded that global spectrum regulation is critical for ensuring efficient use of spectrum, promoting competition, and enabling innovation in wireless technologies.